A novel fluorescent probe for imaging the process of HOCl oxidation and Cys/Hcy reduction in living cells

Zhen Liu; Guoping Li; Yana Wang; Jiulong Li; Yang Mi; Linna Guo; Wenjian Xu; Dapeng Zou; Tiesheng Li; Yangjie Wu

doi:10.1039/C7RA13419C

A novel fluorescent probe for imaging the process of HOCl oxidation and Cys/Hcy reduction in living cells†

Zhen Liu,^a Guoping Li,

*^a Yana Wang,^a Jiulong Li,^a Yang Mi,^b Linna Guo,

^a Wenjian Xu,^a Dapeng Zou,^a Tiesheng Li*^a and Yangjie Wu

*^a

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* Corresponding authors

^a The College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, Henan Province, P. R. China
E-mail: liguoping@zzu.edu.cn

^b School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan Province, P. R. China

Abstract

A new on-off-on fluorescent probe, CMOS, based on coumarin was developed to detect the process of hypochlorous acid (HOCl) oxidative stress and cysteine/homocysteine (Cys/Hcy) reduction. The probe exhibited a fast response, good sensitivity and selectivity. Moreover, it was applied for monitoring the redox process in living cells.

RSC Advances

A novel fluorescent probe for imaging the process of HOCl oxidation and Cys/Hcy reduction in living cells†

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A novel fluorescent probe for imaging the process of HOCl oxidation and Cys/Hcy reduction in living cells

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