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Issue 19, 2018, Issue in Progress
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Efficient protective activity of a planar catechin analogue against radiation-induced apoptosis in rat thymocytes

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Abstract

About two thirds of biological damage due to low linear energy transfer (LET) radiation, such as X-rays and the plateau region of heavy-ion beams, is known to be caused by the hydroxyl radical (˙OH), the most powerful reactive oxygen species (ROS), generated via ionisation and excitation of water molecules. Thus, compounds having an efficient scavenging activity against ROS are expected to exhibit a radioprotective activity. A planar catechin analogue, where an isopropyl fragment was introduced into the catechol ring of (+)-catechin, showed an efficient protective effect against X-ray induced apoptosis in rat thymocytes compared to (+)-catechin. The planar catechin scavenged 2,2-diphenyl-1-picrylhydrazyl radicals (DPPH˙) solubilised in water by β-cyclodextrin about 10-fold faster than (+)-catechin in phosphate buffer (0.1 M, pH 7.4) at 298 K. Furthermore, the experimental log P value of the planar catechin (1.22) is reported to be significantly larger than that of (+)-catechin (0.44). The higher radical-scavenging activity and lipophilicity of the planar catechin than those of (+)-catechin may contribute in part to the higher protective activity against X-ray-induced apoptosis in rat thymocytes.

Graphical abstract: Efficient protective activity of a planar catechin analogue against radiation-induced apoptosis in rat thymocytes

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Publication details

The article was received on 07 Dec 2017, accepted on 02 Mar 2018 and first published on 13 Mar 2018


Article type: Paper
DOI: 10.1039/C7RA13111A
Citation: RSC Adv., 2018,8, 10158-10162
  • Open access: Creative Commons BY license
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    Efficient protective activity of a planar catechin analogue against radiation-induced apoptosis in rat thymocytes

    E. Sekine-Suzuki, I. Nakanishi, K. Imai, M. Ueno, T. Shimokawa, K. Matsumoto and K. Fukuhara, RSC Adv., 2018, 8, 10158
    DOI: 10.1039/C7RA13111A

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