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Issue 4, 2018, Issue in Progress
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A three-dimensional hydroxyapatite/polyacrylonitrile composite scaffold designed for bone tissue engineering

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Abstract

In recent years, various composite scaffolds based on hydroxyapatite have been developed for bone tissue engineering. However, the poor cell survival micro-environment is still the major problem limiting their practical applications in bone repairing and regeneration. In this study, we fabricated a class of fluffy and porous three-dimensional composite fibrous scaffolds consisting of hydroxyapatite and polyacrylonitrile by employing an improved electrospinning technique combined with a bio-mineralization process. The fluffy structure of the hydroxyapatite/polyacrylonitrile composite scaffold ensured the cells would enter the interior of the scaffold and achieve a three-dimensional cell culture. Bone marrow mesenchymal stem cells were seeded into the scaffolds and cultured for 21 days in vitro to evaluate the response of cellular morphology and biochemical activities. The results indicated that the bone marrow mesenchymal stem cells showed higher degrees of growth, osteogenic differentiation and mineralization than those cultured on the two-dimensional hydroxyapatite/polyacrylonitrile composite membranes. The obtained results strongly supported the fact that the novel three-dimensional fluffy hydroxyapatite/polyacrylonitrile composite scaffold had potential application in the field of bone tissue engineering.

Graphical abstract: A three-dimensional hydroxyapatite/polyacrylonitrile composite scaffold designed for bone tissue engineering

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Publication details

The article was received on 15 Nov 2017, accepted on 26 Dec 2017 and first published on 08 Jan 2018


Article type: Paper
DOI: 10.1039/C7RA12449J
Citation: RSC Adv., 2018,8, 1730-1736
  • Open access: Creative Commons BY license
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    A three-dimensional hydroxyapatite/polyacrylonitrile composite scaffold designed for bone tissue engineering

    S. Wu, J. Wang, L. Zou, L. Jin, Z. Wang and Y. Li, RSC Adv., 2018, 8, 1730
    DOI: 10.1039/C7RA12449J

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