Issue 12, 2018

Driving mesenchymal stem cell differentiation from self-assembled monolayers

Abstract

The utilization of self-assembled monolayer (SAM) systems to direct Mesenchymal Stem Cell (MSC) differentiation has been covered in the literature for years, but finding a general consensus pertaining to its exact role over the differentiation of stem cells had been rather challenging. Although there are numerous reports on surface functional moieties activating and inducing differentiation, the results are often different between reports due to the varying surface conditions, such as topography or surface tension. Herein, in view of the complexity of the subject matter, we have sought to catalogue the recent developments around some of the more common functional groups on predominantly hard surfaces and how these chemical groups may influence the overall outcome of the mesenchymal stem cells (MSC) differentiation so as to better establish a clearer underlying relationship between stem cells and their base substratum interactions.

Graphical abstract: Driving mesenchymal stem cell differentiation from self-assembled monolayers

Article information

Article type
Review Article
Submitted
08 Nov 2017
Accepted
27 Jan 2018
First published
09 Feb 2018
This article is Open Access
Creative Commons BY license

RSC Adv., 2018,8, 6551-6564

Driving mesenchymal stem cell differentiation from self-assembled monolayers

L. S. Tew, J. Y. Ching, S. H. Ngalim and Y. L. Khung, RSC Adv., 2018, 8, 6551 DOI: 10.1039/C7RA12234A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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