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Metallic salt-catalyzed direct indium insertion into alkyl iodides and their applications in cross-coupling reactions

Abstract

An efficient method for the synthesis of alkyl indium reagents by means of an indium(III) or lead(II) halide-catalyzed direct insertion of indium into alkyl iodides and their applications in palladium-catalyzed cross-coupling reactions with aryl halides is developed. NMR and ESI-MS analyses indicated that, rather than the formation of the commonly recognized alkyl indium sesquihalide with a formulation of R3In2X3, the formed alkyl indium reagent in the present protocol should be the mixture of an alkyl indium dihalide (RInX2) and a dialkyl indium halide (R2InX) (both of them presumably exist as dimers).

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Publication details

The article was accepted on 03 Dec 2018 and first published on 04 Dec 2018


Article type: Research Article
DOI: 10.1039/C8QO01244J
Citation: Org. Chem. Front., 2018, Accepted Manuscript
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    Metallic salt-catalyzed direct indium insertion into alkyl iodides and their applications in cross-coupling reactions

    B. Chen, C. Wang, Z. Jing, X. Chu, T. Loh and Z. Shen, Org. Chem. Front., 2018, Accepted Manuscript , DOI: 10.1039/C8QO01244J

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