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Purmedermycins A and B, two novel medermycin derivatives from Streptomyces sp. SS17A

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Abstract

Purmedermycin A (1) and purmedermycin B (2), which were isolated from Streptomyces sp. SS17A, feature a rearranged and reconstructed C/D/E ring formed by the fusion of a tryptophan unit and medermycin or menoxymycin B, respectively, making them the first of a new type of medermycin. Their structures were determined by extensive spectroscopic analysis and ECD calculations. Compound 1 exhibited cytotoxicity against PC-3 and HCT-116 cancer cell lines with IC50 values of 1.33 and 4.51 μM, respectively.

Graphical abstract: Purmedermycins A and B, two novel medermycin derivatives from Streptomyces sp. SS17A

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Publication details

The article was received on 07 Nov 2018, accepted on 15 Dec 2018 and first published on 18 Dec 2018


Article type: Research Article
DOI: 10.1039/C8QO01205A
Citation: Org. Chem. Front., 2019, Advance Article
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    Purmedermycins A and B, two novel medermycin derivatives from Streptomyces sp. SS17A

    B. Zhou, Y. Jiang, J. Li, H. Zhang, W. Ding and Z. Ma, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C8QO01205A

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