Issue 22, 2018
From the journal:

Organic Chemistry Frontiers

Asymmetric phase-transfer catalysed β-addition of isoxazolidin-5-ones to MBH carbonates†

Vito Capaccio,ab   Katharina Zielke,a   Andreas Eitzinger,a   Antonio Massa,b   Laura Palombi, ORCID logo b   Kirill Faustc  and  Mario Waser ORCID logo *a  

* Corresponding authors

a Institute of Organic Chemistry, Johannes Kepler University Linz, Altenbergerstr. 69, 4040 Linz, Austria
E-mail: mario.waser@jku.at

b Dipartimento di Chimica e Biologia, Università di Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy

c Institute of Catalysis, Johannes Kepler University Linz, Altenbergerstr. 69, 4040 Linz, Austria

Abstract

A novel high yielding, enantio- and diastereoselective protocol for the synthesis of α-allylated highly functionalised β-amino acid derivatives by adding isoxazolidin-5-ones to MBH carbonates under asymmetric phase-transfer catalysis has been developed.

Graphical abstract: Asymmetric phase-transfer catalysed β-addition of isoxazolidin-5-ones to MBH carbonates

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Article information

DOI
https://doi.org/10.1039/C8QO01057A
Article type
Research Article
Submitted
01 Oct 2018
Accepted
11 Oct 2018
First published
12 Oct 2018
This article is Open Access
Creative Commons BY license

Org. Chem. Front., 2018,5, 3336-3340

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Asymmetric phase-transfer catalysed β-addition of isoxazolidin-5-ones to MBH carbonates

V. Capaccio, K. Zielke, A. Eitzinger, A. Massa, L. Palombi, K. Faust and M. Waser, Org. Chem. Front., 2018, 5, 3336 DOI: 10.1039/C8QO01057A

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