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Issue 22, 2018
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Asymmetric phase-transfer catalysed β-addition of isoxazolidin-5-ones to MBH carbonates

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Abstract

A novel high yielding, enantio- and diastereoselective protocol for the synthesis of α-allylated highly functionalised β-amino acid derivatives by adding isoxazolidin-5-ones to MBH carbonates under asymmetric phase-transfer catalysis has been developed.

Graphical abstract: Asymmetric phase-transfer catalysed β-addition of isoxazolidin-5-ones to MBH carbonates

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Publication details

The article was received on 01 Oct 2018, accepted on 11 Oct 2018 and first published on 12 Oct 2018


Article type: Research Article
DOI: 10.1039/C8QO01057A
Citation: Org. Chem. Front., 2018,5, 3336-3340
  • Open access: Creative Commons BY license
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    Asymmetric phase-transfer catalysed β-addition of isoxazolidin-5-ones to MBH carbonates

    V. Capaccio, K. Zielke, A. Eitzinger, A. Massa, L. Palombi, K. Faust and M. Waser, Org. Chem. Front., 2018, 5, 3336
    DOI: 10.1039/C8QO01057A

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