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Direct construction of benzimidazo[l,2-c]quinazolin-6-ones via metal-free oxidative C–C bond cleavage

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Abstract

A highly regioselective C–C bond cleavage/amination of isatins has been developed for the synthesis of benzimidazo[1,2-c]quinazolin-6-ones by reacting with o-phenylene diamines. This practical transition-metal-free method is operationally simple, enabling the C–C bond cleavage and triple C–N bond formation, wherein molecular oxygen is the sole required oxidant.

Graphical abstract: Direct construction of benzimidazo[l,2-c]quinazolin-6-ones via metal-free oxidative C–C bond cleavage

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Publication details

The article was received on 26 Sep 2018, accepted on 23 Oct 2018 and first published on 25 Oct 2018


Article type: Research Article
DOI: 10.1039/C8QO01039K
Citation: Org. Chem. Front., 2018, Advance Article
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    Direct construction of benzimidazo[l,2-c]quinazolin-6-ones via metal-free oxidative C–C bond cleavage

    P. Li, C. Yan, S. Zhu, S. Liu and L. Zou, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO01039K

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