Nucleophile-controlled mono- and bis-phosphonation of amino-2-en-1-ones via catalyst-free C(sp3)–N bond cleavage

Abstract

A catalyst-free mono- and bis-phosphonation of amino-2-en-1-ones via C(sp³)–N bond cleavage is described. This reaction proceeds through an interaction of substrates in the absence of any external catalyst or additive, and under air conditions. The selectivity of the mono-phosphonation and bis-phosphonation was controlled by the phosphorus nucleophiles with their nucleophilicities.