Issue 3, 2019

Spirocyclization of keto-ynesulfonamides promoted by quaternary ammonium salts

Abstract

Spirocyclization of keto-ynesulfonamides with quaternary ammonium salts was performed to access aza-spiro compounds. Exclusive E-configured 5-exo-dig compounds were isolated from keto-ynesulfonamides substituted by an aryl- or a vinyl group, whereas 6-endo-dig compounds were favored from terminal ynesulfonamides.

Graphical abstract: Spirocyclization of keto-ynesulfonamides promoted by quaternary ammonium salts

Supplementary files

Article information

Article type
Research Article
Submitted
29 Aug 2018
Accepted
13 Dec 2018
First published
14 Dec 2018

Org. Chem. Front., 2019,6, 373-376

Spirocyclization of keto-ynesulfonamides promoted by quaternary ammonium salts

F. Beltran, L. Andna and L. Miesch, Org. Chem. Front., 2019, 6, 373 DOI: 10.1039/C8QO00937F

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