Issue 19, 2018

Cp*Rh(iii)-catalyzed annulation of N-methoxybenzamide with 1,4,2-bisoxazol-5-one toward 2-aryl quinazolin-4(3H)-one derivatives

Abstract

A [Cp*RhIII]-catalyzed annulation of N-methoxybenzamide with 1,4,2-bisoxazol-5-one was developed, affording a series of 2-aryl quinazolin-4(3H)-one derivatives in moderate to excellent yields with good functional group tolerance. This reaction proceeded with sequential regioselective ortho-C–H amidation and cyclization.

Graphical abstract: Cp*Rh(iii)-catalyzed annulation of N-methoxybenzamide with 1,4,2-bisoxazol-5-one toward 2-aryl quinazolin-4(3H)-one derivatives

Supplementary files

Article information

Article type
Research Article
Submitted
31 Jul 2018
Accepted
02 Sep 2018
First published
03 Sep 2018

Org. Chem. Front., 2018,5, 2880-2884

Cp*Rh(III)-catalyzed annulation of N-methoxybenzamide with 1,4,2-bisoxazol-5-one toward 2-aryl quinazolin-4(3H)-one derivatives

H. Xiong, S. Xu, S. Sun and J. Cheng, Org. Chem. Front., 2018, 5, 2880 DOI: 10.1039/C8QO00800K

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