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Issue 20, 2018
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Iridium-catalyzed oxidative Ar–H/Ar–H cross-coupling of primary benzamides with thiophenes

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Abstract

(2-Thienyl)benzamide frameworks are prevalent in pharmaceuticals and advanced materials. Herein, we disclose an iridium-catalyzed oxidative Ar–H/Ar–H cross-coupling reaction of primary benzamides with thiophenes, which provides a rapid pathway to (2-thienyl)benzamide skeletons. Furthermore, the coupled products can be transformed to the corresponding important thiophene-fused 1-isoquinolinones via a copper-catalyzed intramolecular annulation.

Graphical abstract: Iridium-catalyzed oxidative Ar–H/Ar–H cross-coupling of primary benzamides with thiophenes

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Publication details

The article was received on 31 Jul 2018, accepted on 06 Sep 2018 and first published on 06 Sep 2018


Article type: Research Article
DOI: 10.1039/C8QO00796A
Citation: Org. Chem. Front., 2018,5, 2930-2933

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    Iridium-catalyzed oxidative Ar–H/Ar–H cross-coupling of primary benzamides with thiophenes

    G. Tan, C. Ran and J. You, Org. Chem. Front., 2018, 5, 2930
    DOI: 10.1039/C8QO00796A

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