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Issue 21, 2018
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Selective modification of natural nucleophilic residues in peptides and proteins using arylpalladium complexes

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Abstract

Transition metal-mediated modification of peptides and proteins is emerging as a powerful method for their selective functionalization and bioconjugation, particularly for native peptides and proteins bearing no unnatural bioorthogonal handles. The modified peptides and proteins are useful synthetic reagents needed in both biochemical and biophysical studies, as well as in pharmaceutical research. This mini-review surveys recent developments of regio- and chemoselective arylation reactions of the natural nucleophilic residues within unprotected peptides and proteins, promoted by arylpalladium complexes. These reactions exhibited high selectivities and excellent biocompatibility, proceeded under mild reaction conditions, and have a wide range of applications. They exemplify the advantages and potential of organometallic palladium complexes in bioconjugation, and are expected to inspire future studies on transition metal-mediated biocompatible modification reactions.

Graphical abstract: Selective modification of natural nucleophilic residues in peptides and proteins using arylpalladium complexes

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Publication details

The article was received on 31 Jul 2018, accepted on 07 Sep 2018 and first published on 21 Sep 2018


Article type: Review Article
DOI: 10.1039/C8QO00765A
Citation: Org. Chem. Front., 2018,5, 3186-3193
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    Selective modification of natural nucleophilic residues in peptides and proteins using arylpalladium complexes

    W. Cheng, X. Lu, J. Shi and L. Liu, Org. Chem. Front., 2018, 5, 3186
    DOI: 10.1039/C8QO00765A

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