Issue 12, 2018
From the journal:

Organic Chemistry Frontiers

Metal-free direct oxidative C–C bond coupling of pyrazolones and quinoxalinones†

Saowanee Toonchue,a   Ladawan Sumunnee,a   Khamphee Phomphrai ORCID logo b  and  Sirilata Yotphan ORCID logo *a  

* Corresponding authors

a Center of Excellence for Innovation in Chemistry (PERCH-CIC), Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
E-mail: sirilata.yot@mahidol.ac.th

b Department of Materials Science and Engineering, School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Wangchan, Rayong, Thailand

Abstract

A highly efficient transition metal-free oxidative chemo- and regioselective C–C bond coupling of pyrazolones and quinoxalinones mediated by K2S2O8 is described. This reaction can be conveniently carried out under mild conditions and gives various hydroxy-pyrazolyl quinoxalinone products in moderate to excellent yields in a short reaction time.

Graphical abstract: Metal-free direct oxidative C–C bond coupling of pyrazolones and quinoxalinones

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Article information

DOI
https://doi.org/10.1039/C8QO00328A
Article type
Research Article
Submitted
30 Mar 2018
Accepted
29 Apr 2018
First published
02 May 2018

Org. Chem. Front., 2018,5, 1928-1932

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Metal-free direct oxidative C–C bond coupling of pyrazolones and quinoxalinones

S. Toonchue, L. Sumunnee, K. Phomphrai and S. Yotphan, Org. Chem. Front., 2018, 5, 1928 DOI: 10.1039/C8QO00328A

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