Copper/amine-catalyzed formal regioselective [3 + 2] cycloaddition of an α,β-unsaturated O-acetyl oxime with enals

Abstract

A novel copper/amine co-catalyzed formal regioselective [3 + 2] cycloaddition reaction of an O-acyl oxime with α,β-unsaturated aldehydes is developed. This novel transformation provided an efficient protocol for the assembly of multifunctionalized pyrroles with good yields and diverse functional group tolerance.