Cobalt-catalyzed asymmetric reactions of heterobicyclic alkenes with in situ generated organozinc halides

Abstract

A general strategy for the asymmetric allylation and benzylation of heterobicyclic alkenes is described by employing in situ generated organozinc halides. This methodology features the application of a co-catalytic system comprising chiral cobalt complex and Lewis acid, which deliver both the asymmetric ring opening products of oxabenzonorbornadienes and the asymmetric addition products of azabenzonorbornadienes, respectively.