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Issue 4, 2018
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Palladium-catalyzed direct C–H ethoxycarbonylation of 2-aryl-1,2,3-triazoles and efficient synthesis of suvorexant

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Abstract

Efficient palladium-catalyzed C–H ethoxycarbonylation of 2-aryl-1,2,3-triazoles was developed by using diethyl azodicarboxylate as the esterification reagent. A wide variety of aryl esters containing 1,2,3-triazoles were obtained in moderate to good yields. In addition, density functional theory calculations were used to enhance the mechanistic studies.

Graphical abstract: Palladium-catalyzed direct C–H ethoxycarbonylation of 2-aryl-1,2,3-triazoles and efficient synthesis of suvorexant

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Article information


Submitted
18 Oct 2017
Accepted
13 Nov 2017
First published
15 Nov 2017

Org. Chem. Front., 2018,5, 648-652
Article type
Research Article

Palladium-catalyzed direct C–H ethoxycarbonylation of 2-aryl-1,2,3-triazoles and efficient synthesis of suvorexant

R. Sang, Y. Zheng, H. Zhang, X. Wu, Q. Wang, L. Hai and Y. Wu, Org. Chem. Front., 2018, 5, 648
DOI: 10.1039/C7QO00945C

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