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Issue 30, 2018
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Cd2+ coordination: an efficient structuring switch for polypeptide polymers

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Abstract

Stimuli-responsive polypeptides have practical applications in devices and therapeutic delivery. Here we report that coordination to Cd2+ metal species can be used as a robust stimulus to control both, α-helix and β-sheet secondary structuring of polypeptide polymers whose metal responsiveness was achieved in the presence of a competitive buffer. As evidenced by circular dichroism analyses, secondary structuring can be easily reversed using “sequestering” external ligands, such as EDTA, that are widely used in industry, to finally design a multivalent polypeptide backbone combining metal responsiveness to two other stimuli, pH and redox conditions.

Graphical abstract: Cd2+ coordination: an efficient structuring switch for polypeptide polymers

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Publication details

The article was received on 01 Jun 2018, accepted on 13 Jun 2018 and first published on 13 Jun 2018


Article type: Communication
DOI: 10.1039/C8PY00810H
Citation: Polym. Chem., 2018,9, 4100-4107
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    Cd2+ coordination: an efficient structuring switch for polypeptide polymers

    J. Aujard-Catot, M. Nguyen, C. Bijani, G. Pratviel and C. Bonduelle, Polym. Chem., 2018, 9, 4100
    DOI: 10.1039/C8PY00810H

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