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Issue 8, 2018
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Terpyridine derivatives as “turn-on” fluorescence chemosensors for the selective and sensitive detection of Zn2+ ions in solution and in live cells

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Abstract

A terpyridine based compound L1 was designed and synthesized as an “off–on” chemosensor for the detection of Zn2+. Chemosensor L1 showed excellent selectivity and sensitivity toward Zn2+ by exhibiting a large fluorescence enhancement (∼51-fold) at 370 nm whereas other competitive metal ions did not show any noticeable change in the emission spectra of chemosensor L1. The chemosensor (L1) was shown to detect Zn2+ ions down to 9.76 μM at pH 7.4. However, chemosensor L1 binds Zn2+ in a 1 : 2 ratio (receptor : metal) with an association constant of 1.85 × 104 (R2 = 0.993) and this 1 : 2 stoichiometric fashion is established on the basis of a Job plot and mass spectroscopy. DFT/TD-DFT calculations were carried out to understand the binding nature, coordination features and electronic properties of L1 and the L1–2Zn2+ complex. In addition, this “turn-on” fluorescence probe was effectively used to image intracellular Zn2+ ions in cultured MDA-MB-468 cells.

Graphical abstract: Terpyridine derivatives as “turn-on” fluorescence chemosensors for the selective and sensitive detection of Zn2+ ions in solution and in live cells

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Publication details

The article was received on 01 May 2018, accepted on 06 Jun 2018 and first published on 06 Jun 2018


Article type: Paper
DOI: 10.1039/C8PP00186C
Citation: Photochem. Photobiol. Sci., 2018,17, 1068-1074
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    Terpyridine derivatives as “turn-on” fluorescence chemosensors for the selective and sensitive detection of Zn2+ ions in solution and in live cells

    T. Mandal, A. Hossain, A. Dhara, A. Al Masum, S. Konar, S. K. Manna, S. K. Seth, S. Pathak and S. Mukhopadhyay, Photochem. Photobiol. Sci., 2018, 17, 1068
    DOI: 10.1039/C8PP00186C

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