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Impact of Infrared Radiation on UVB-induced Skin Tumourigenesis in Wild Type C57BL/6 Mice

Abstract

Although infrared radiation (IR) represents more than 50 % of the solar radiation reaching the earth’s surface, this waveband has been hardly investigated in terms of tumorigenesis. The objective of the present study was to investigate the influence of IR on ultraviolet B (UVB)-induced carcinogenesis in male and female wild type mice. For that purpose, male and female C57BL/6N mice were subjected to a long-term irradiation protocol. Mice were irradiated once neonatally and from the age of eight weeks during 36 weeks with a cumulative dose of 576 kJ m-2 UVB and/or 78,895 kJ m-2 IR. In order to resemble natural sun irradiations, exposures to physiologic doses of UVB and IR were performed simultaneously. Mice were screened for arising lesions twice a week. Lesions were excised and histologically diagnosed. Kaplan-Meier analyses were carried out and the counts and estimated counts of lesions in the UVB and IR+UVB-exposed groups in male and female mice was compared. We found that IR-exposure did not change the number of epithelial malignant tumours in UVB-exposed wild type mice. In combination with IR there was a tendency of more tumours with increased malignancy: 23 vs. seven spindle cell shaped sarcomas and seven vs. two MelA+/S100+ tumours in groups of 35 C57BL/6 mice. IR did not influence UVB-induced carcinogenesis differently in male and female mice. However, comparing UVB and sham irradiated animals irrespective of IR exposure, UVB-induced non-epithelial tumours arose significantly earlier in male than in female mice.

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Publication details

The article was received on 20 Mar 2018, accepted on 06 Oct 2018 and first published on 08 Oct 2018


Article type: Paper
DOI: 10.1039/C8PP00118A
Citation: Photochem. Photobiol. Sci., 2018, Accepted Manuscript
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    Impact of Infrared Radiation on UVB-induced Skin Tumourigenesis in Wild Type C57BL/6 Mice

    S. Kimeswenger, B. Sterniczky, A. M. Kramer, K. Tillmann, J. Gamper, D. Foedinger, P. Petzelbauer and C. Jantschitsch, Photochem. Photobiol. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8PP00118A

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