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Issue 7, 2018
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Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering

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Abstract

The structural dynamics of insulin hexamer dissociation were studied by the photoinduced temperature jump technique and monitored by time-resolved X-ray scattering. The process of hexamer dissociation was found to involve several transient intermediates, including an expanded hexamer and an unstable tetramer. Our findings provide insights into the mechanisms of protien–protein association.

Graphical abstract: Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering

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Publication details

The article was received on 25 Jan 2018, accepted on 24 May 2018 and first published on 25 May 2018


Article type: Communication
DOI: 10.1039/C8PP00034D
Citation: Photochem. Photobiol. Sci., 2018,17, 874-882
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    Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering

    D. Rimmerman, D. Leshchev, D. J. Hsu, J. Hong, B. Abraham, I. Kosheleva, R. Henning and L. X. Chen, Photochem. Photobiol. Sci., 2018, 17, 874
    DOI: 10.1039/C8PP00034D

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