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Issue 11, 2018
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The good, the bad, and the ugly – controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy

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Abstract

Singlet oxygen, although integral to photodynamic therapy, is notoriously uncontrollable, suffers from poor selectivity and has fast decomposition rates in biological media. Across the scientific community, there is a conscious effort to refine singlet oxygen interactions and initiate selective and controlled release to produce a consistent and reproducible therapeutic effect in target tissue. This perspective aims to provide an insight into the contemporary design principles behind photosensitizers and drug delivery systems that depend on a singlet oxygen response or controlled release. The discussion will be accompanied by in vitro and in vivo examples, in an attempt to highlight advancements in the field and future prospects for the more widespread application of photodynamic therapy.

Graphical abstract: The good, the bad, and the ugly – controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy

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Publication details

The article was received on 11 Jan 2018, accepted on 16 Mar 2018 and first published on 20 Mar 2018


Article type: Perspective
DOI: 10.1039/C8PP00008E
Citation: Photochem. Photobiol. Sci., 2018,17, 1490-1514
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    The good, the bad, and the ugly – controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy

    S. Callaghan and M. O. Senge, Photochem. Photobiol. Sci., 2018, 17, 1490
    DOI: 10.1039/C8PP00008E

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