Jump to main content
Jump to site search


Ruthenium-catalyzed synthesis of indole derivatives from N-aryl-2-aminopyridines and alpha-carbonyl sulfoxonium ylides

Author affiliations

Abstract

Indole is a ubiquitous structural motif with important applications in many areas of chemistry. Given this, a simple and efficient Ru(II)-catalyzed synthesis of indole via intermolecular annulation of N-aryl-2-aminopyridines and sulfoxonium ylides was proposed and accomplished. Excellent selectivity and good functional group tolerance of this transformation were observed. This protocol provides easy access to a wide variety of useful indoles in the presence of a commercially available [Ru(p-cymene)Cl2]2 catalyst. A possible mechanism for the reaction pathway was also proposed. More importantly, this reaction will offer a useful method for the construction of enantioenriched indole frameworks.

Graphical abstract: Ruthenium-catalyzed synthesis of indole derivatives from N-aryl-2-aminopyridines and alpha-carbonyl sulfoxonium ylides

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Nov 2018, accepted on 03 Dec 2018 and first published on 05 Dec 2018


Article type: Communication
DOI: 10.1039/C8OB02818D
Citation: Org. Biomol. Chem., 2019, Advance Article
  •   Request permissions

    Ruthenium-catalyzed synthesis of indole derivatives from N-aryl-2-aminopyridines and alpha-carbonyl sulfoxonium ylides

    X. Cui, Z. Ban, W. Tian, F. Hu, X. Zhou, H. Ma, Z. Zhan and G. Huang, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C8OB02818D

Search articles by author

Spotlight

Advertisements