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Issue 47, 2018
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Identification of thienopyridine carboxamides as selective binders of HIV-1 trans Activation Response (TAR) and Rev Response Element (RRE) RNAs

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Abstract

Small organic molecules that can selectively bind to RNA with specificity are relatively rare. Here we report the synthesis, biochemical and structural studies of thienopyridine carboxamide derivatives with the capacity of selectively recognizing and binding with HIV-1 TAR and RRE RNAs that are essential elements for viral replication.

Graphical abstract: Identification of thienopyridine carboxamides as selective binders of HIV-1 trans Activation Response (TAR) and Rev Response Element (RRE) RNAs

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Publication details

The article was received on 06 Nov 2018, accepted on 15 Nov 2018 and first published on 16 Nov 2018


Article type: Paper
DOI: 10.1039/C8OB02753F
Citation: Org. Biomol. Chem., 2018,16, 9191-9196
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    Identification of thienopyridine carboxamides as selective binders of HIV-1 trans Activation Response (TAR) and Rev Response Element (RRE) RNAs

    X. Li, L. Liu and L. Cheng, Org. Biomol. Chem., 2018, 16, 9191
    DOI: 10.1039/C8OB02753F

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