Jump to main content
Jump to site search

Issue 48, 2018
Previous Article Next Article

Practical regio- and stereoselective azidation and amination of terminal alkenes

Author affiliations

Abstract

There is significant interest in developing more rapid and efficient production of nitrogen-containing allylic compounds, as widely used in various syntheses. This work reports a variety of allylic azides and allylic amines synthesized by an efficient, new one-pot protocol that employs readily available terminal alkenes as starting materials. This method is highly regio- and stereoselective, affording the linear (E)-isomer, under metal-free conditions. This process tolerates several functional groups including halogen-containing molecules; it is general for azides and amine nucleophiles; and, adducts were obtained in good yields.

Graphical abstract: Practical regio- and stereoselective azidation and amination of terminal alkenes

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Nov 2018, accepted on 21 Nov 2018 and first published on 21 Nov 2018


Article type: Communication
DOI: 10.1039/C8OB02734J
Citation: Org. Biomol. Chem., 2018,16, 9354-9358
  •   Request permissions

    Practical regio- and stereoselective azidation and amination of terminal alkenes

    O. S. Ojo, O. Miranda, K. C. Baumgardner and A. Bugarin, Org. Biomol. Chem., 2018, 16, 9354
    DOI: 10.1039/C8OB02734J

Search articles by author

Spotlight

Advertisements