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Substrate selectivity and its mechanistic insight of the photo-responsive non-nucleoside triphosphate for myosin and kinesin

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Abstract

Linear motor proteins including kinesin and myosin are promising biomaterials for developing nano-devices. Photoswitchable substrates of these biomotors can be used to optically regulate the motility of their associated cytoskeletal filaments in in vitro systems. Here, we describe the discovery of the myosin selective azobenzene-tethered triphosphate. It enables the specific photocontrol over myosin in a reversible mode with the composite motility assay composed of both kinesin and myosin. The mechanistic insight into this myosin selectivity is also explained with the docking simulation study.

Graphical abstract: Substrate selectivity and its mechanistic insight of the photo-responsive non-nucleoside triphosphate for myosin and kinesin

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Publication details

The article was received on 01 Nov 2018, accepted on 03 Dec 2018 and first published on 04 Dec 2018


Article type: Paper
DOI: 10.1039/C8OB02714E
Citation: Org. Biomol. Chem., 2019, Advance Article
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    Substrate selectivity and its mechanistic insight of the photo-responsive non-nucleoside triphosphate for myosin and kinesin

    Md. J. Islam, K. Matsuo, H. M. Menezes, M. Takahashi, H. Nakagawa, A. Kakugo, K. Sada and N. Tamaoki, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C8OB02714E

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