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Issue 48, 2018
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Copper-catalyzed three-component synthesis of pyrimidines from amidines and alcohols

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Abstract

An efficient copper-catalyzed one-pot three-component reaction of amidines, primary alcohols and secondary alcohols has been developed to synthesize multisubstituted pyrimidines. The significant merits of this method involve high atom efficiency, good functional group tolerance and operational simplicity.

Graphical abstract: Copper-catalyzed three-component synthesis of pyrimidines from amidines and alcohols

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Publication details

The article was received on 31 Oct 2018, accepted on 28 Nov 2018 and first published on 29 Nov 2018


Article type: Paper
DOI: 10.1039/C8OB02694G
Citation: Org. Biomol. Chem., 2018,16, 9487-9491
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    Copper-catalyzed three-component synthesis of pyrimidines from amidines and alcohols

    T. Shi, F. Qin, Q. Li and W. Zhang, Org. Biomol. Chem., 2018, 16, 9487
    DOI: 10.1039/C8OB02694G

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