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Issue 47, 2018
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Direct halosulfenylation of benzo[b]furans: a metal-free synthesis of 3-halo-2-thiobenzo[b]furans

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Abstract

The first example of the direct halosulfenylation of benzo[b]furans with commercially available disulfides and N-halosuccinimides has been achieved, providing an efficient metal-free synthetic pathway to access diverse 3-halo-2-thiobenzo[b]furans in moderate to excellent yields. In particular, a halogen (e.g., bromo or iodo) substituent on the benzo[b]furan ring is amenable for further synthetic elaborations thereby broadening the diversity of the products.

Graphical abstract: Direct halosulfenylation of benzo[b]furans: a metal-free synthesis of 3-halo-2-thiobenzo[b]furans

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Publication details

The article was received on 30 Oct 2018, accepted on 19 Nov 2018 and first published on 19 Nov 2018


Article type: Paper
DOI: 10.1039/C8OB02680G
Citation: Org. Biomol. Chem., 2018,16, 9204-9210
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    Direct halosulfenylation of benzo[b]furans: a metal-free synthesis of 3-halo-2-thiobenzo[b]furans

    Q. Zhen, D. Huang, Y. Shao, T. Cheng and J. Chen, Org. Biomol. Chem., 2018, 16, 9204
    DOI: 10.1039/C8OB02680G

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