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Issue 48, 2018
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Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system

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Abstract

Using a highly effective heterologous expression system, the YM-216391 (1) biosynthetic gene cluster was engineered to yield aurantizolicin (2) and the hybrid compound 3. Both of these compounds were isolated and fully structurally characterised and the bioactivity was evaluated. The results indicate that compound 3 exhibits significantly improved antitumor activity.

Graphical abstract: Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system

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Publication details

The article was received on 28 Oct 2018, accepted on 22 Nov 2018 and first published on 27 Nov 2018


Article type: Communication
DOI: 10.1039/C8OB02665C
Citation: Org. Biomol. Chem., 2018,16, 9373-9376
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    Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system

    Z. Pei, M. Yang, L. Li, X. Jian, Y. Yin, D. Li, H. Pan, Y. Lu, W. Jiang and G. Tang, Org. Biomol. Chem., 2018, 16, 9373
    DOI: 10.1039/C8OB02665C

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