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Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery

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Abstract

We demonstrate a proof of principle for a new approach in the development of a drug delivery system. A positively charged prodrug (phenol) can form a stable inclusion complex with CB[7], which enables more efficient delivery of the prodrug. After photochemical transformation (photoactivation) inside the complex, an active drug quinone methide (QM) is formed and released from the complex, since it is a neutral molecule and forms a less stable complex with CB[7].

Graphical abstract: Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery

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Publication details

The article was received on 20 Oct 2018, accepted on 05 Nov 2018 and first published on 05 Nov 2018


Article type: Communication
DOI: 10.1039/C8OB02605J
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery

    Đ. Škalamera, M. Matković, L. Uzelac, M. Kralj, K. Mlinarić-Majerski, C. Bohne and N. Basarić, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02605J

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