Jump to main content
Jump to site search


Asymmetric transfer hydrogenation of cycloalkyl vinyl ketones to allylic alcohols catalyzed by ruthenium amido complexes

Author affiliations

Abstract

A chemoselective 1,2-reduction of cycloalkyl vinyl ketones via asymmetric transfer hydrogenation is described. The reduction proceeded smoothly with a chiral diamine ruthenium complex as a catalyst and a HCOOH–NEt3 azeotrope as both a hydrogen source and solvent under mild conditions. A wide range of 1-cycloalkyl chiral allylic alcohols were obtained in good yields and up to 87% ee. It was found that the alkyl group plays an important role in the enantioselectivity.

Graphical abstract: Asymmetric transfer hydrogenation of cycloalkyl vinyl ketones to allylic alcohols catalyzed by ruthenium amido complexes

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Oct 2018, accepted on 04 Dec 2018 and first published on 04 Dec 2018


Article type: Paper
DOI: 10.1039/C8OB02604A
Citation: Org. Biomol. Chem., 2019, Advance Article
  •   Request permissions

    Asymmetric transfer hydrogenation of cycloalkyl vinyl ketones to allylic alcohols catalyzed by ruthenium amido complexes

    S. Liu, P. Cui, J. Wang, H. Zhou, Q. Liu and J. Lv, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C8OB02604A

Search articles by author

Spotlight

Advertisements