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An enantioselective synthesis of α-alkylated pyrroles via cooperative isothiourea/palladium catalysis

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Abstract

Herein we describe the direct enantioselective Lewis base/Pd catalysed α-allylation of pyrrole acetic acid esters. This provides high isolated yields of highly enantioenriched products and exhibits broad reaction scope with respect to both reaction partners. The products can be readily elaborated in a manner which points towards potential applications in target directed synthesis.

Graphical abstract: An enantioselective synthesis of α-alkylated pyrroles via cooperative isothiourea/palladium catalysis

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Publication details

The article was received on 20 Oct 2018, accepted on 20 Nov 2018 and first published on 28 Nov 2018


Article type: Communication
DOI: 10.1039/C8OB02600A
Citation: Org. Biomol. Chem., 2018, Advance Article
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    An enantioselective synthesis of α-alkylated pyrroles via cooperative isothiourea/palladium catalysis

    W. Rush Scaggs, T. D. Scaggs and T. N. Snaddon, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02600A

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