Jump to main content
Jump to site search

Issue 47, 2018
Previous Article Next Article

A gold-catalyzed cycloisomerization/aerobic oxidation cascade strategy for 2-aryl indenones from 1,5-enynes

Author affiliations

Abstract

A unique gold(I)-catalyzed 5-endo-dig cyclization/aerobic oxidation cascade strategy from 1,5-enyne substrates with molecular oxygen as the oxidant to yield the indenone was described. The reaction mechanism was studied by heavy atom labelling and some related experiments. This method was applied to the formal total synthesis of isoprekinamycin.

Graphical abstract: A gold-catalyzed cycloisomerization/aerobic oxidation cascade strategy for 2-aryl indenones from 1,5-enynes

Back to tab navigation

Supplementary files

Publication details

The article was received on 17 Oct 2018, accepted on 14 Nov 2018 and first published on 15 Nov 2018


Article type: Communication
DOI: 10.1039/C8OB02582G
Citation: Org. Biomol. Chem., 2018,16, 9147-9151
  •   Request permissions

    A gold-catalyzed cycloisomerization/aerobic oxidation cascade strategy for 2-aryl indenones from 1,5-enynes

    J. Guo, X. Peng, X. Wang, F. Xie, X. Zhang, G. Liang, Z. Sun, Y. Liu, M. Cheng and Y. Liu, Org. Biomol. Chem., 2018, 16, 9147
    DOI: 10.1039/C8OB02582G

Search articles by author

Spotlight

Advertisements