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Taiwanoids A–D, four dimeric diterpenoids featuring tetracyclic [7. 75, 9. 4. 05, 10. 08, 9] octodecane from Taiwania cryptomerioidesim

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Abstract

Biogenesis-inspired chemical research of the leaves of Taiwania cryptomerioides afforded four unprecedented dimeric diterpenes, featuring a tetracyclic [7. 75, 9. 4. 05, 10. 08, 9] octodecane core: taiwanoids A–D (1–4). The structures of these compounds were determined on the basis of comprehensive spectral analysis, chemical conversions and X-ray crystallography. A possible biosynthetic pathway for compounds 1–4 was proposed. Compounds 2 and 3 exerted a 5.37 and 6.26-fold potentiation effect on bortezmib (BTZ) susceptibility at a tested concentration of 20 μM, respectively.

Graphical abstract: Taiwanoids A–D, four dimeric diterpenoids featuring tetracyclic [7. 75, 9. 4. 05, 10. 08, 9] octodecane from Taiwania cryptomerioidesim

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Publication details

The article was received on 16 Oct 2018, accepted on 08 Nov 2018 and first published on 09 Nov 2018


Article type: Paper
DOI: 10.1039/C8OB02566E
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Taiwanoids A–D, four dimeric diterpenoids featuring tetracyclic [7. 75, 9. 4. 05, 10. 08, 9] octodecane from Taiwania cryptomerioidesim

    W. Wang, D. Zhu, J. Luo, F. Liu, C. Chen, T. Zhu, L. Li, C. Han, J. Luo and L. Kong, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02566E

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