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Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium

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Abstract

Crotonols A and B (1 and 2), two tigliane diterpenoids featuring a rare C-7/C-14 cyclized and novel 5/7/7-fused carbon skeleton, along with the known tigliane wallichiioid A, were isolated from the leaves of Croton tiglium. Their structures were determined through spectroscopic methods, X-ray crystallography and ECD analysis. To the best of our knowledge, crotonol B (2) represents the first example of 13,14-seco-tigliane diterpenoids. Crotonols A and B displayed strong cytotoxic activities against the K562 cell line with IC50 values of 0.20 and 0.21 μM, respectively. Furthermore, crotonol A promoted the apoptosis of K562 cells through the cleavage of PARP and the accumulation of bax as well as the degradation of bcl-2.

Graphical abstract: Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium

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Publication details

The article was received on 11 Oct 2018, accepted on 05 Dec 2018 and first published on 06 Dec 2018


Article type: Paper
DOI: 10.1039/C8OB02519C
Citation: Org. Biomol. Chem., 2019, Advance Article
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    Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium

    J. Wang, L. Qin, B. Zhao, L. Cai, Z. Zhong, Y. Liu and X. Zhou, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C8OB02519C

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