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Asymmetric synthesis of β-amino ketones by using cinchona alkaloid-based chiral phase transfer catalysts

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Abstract

A highly enantioselective nucleophilic addition of ketones to imines catalyzed by chiral phase-transfer catalysts (N-quaternised cinchona alkaloid ammonium salts) has been developed, and the process affords the Mannich reaction products with tertiary stereocenters in good to high yields (up to 95%) with excellent enantioselectivities (up to 97% ee).

Graphical abstract: Asymmetric synthesis of β-amino ketones by using cinchona alkaloid-based chiral phase transfer catalysts

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Publication details

The article was received on 06 Oct 2018, accepted on 31 Oct 2018 and first published on 01 Nov 2018


Article type: Communication
DOI: 10.1039/C8OB02484G
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Asymmetric synthesis of β-amino ketones by using cinchona alkaloid-based chiral phase transfer catalysts

    W. Li, Y. Wang and D. Xu, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02484G

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