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Issue 7, 2019
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ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light

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Abstract

We report a high-affinity photoswitchable DNA binder, which displays different nucleosome-binding capacities upon visible-light irradiation. Both photochemical and DNA-recognition properties were examined by UV-Vis, HPLC, CD spectroscopy, NMR, FID assays, EMSA and DLS. Our probe sets the basis for developing new optoepigenetic tools for conditional modulation of nucleosomal DNA accessibility.

Graphical abstract: ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light

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Article information


Submitted
20 Sep 2018
Accepted
19 Dec 2018
First published
21 Dec 2018

Org. Biomol. Chem., 2019,17, 1827-1833
Article type
Communication

ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light

B. Heinrich, K. Bouazoune, M. Wojcik, U. Bakowsky and O. Vázquez, Org. Biomol. Chem., 2019, 17, 1827
DOI: 10.1039/C8OB02343C

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