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Synthesis of the β-linked GalNAc-Kdo Disaccharide Antigen of the Capsular Polysaccharide of Kingella kingae KK01

Abstract

The first construction of the challenging β-(1→5)-linked GalNAc-Kdo skeleton is described for the synthesis of the disaccharide antigen of the capsular polysaccharide of Kingella kingae KK01. TfOH-catalyzed glycosylation of N-Troc-protected D-galactosaminyl N-phenyl trifluoroacetimidate with sterically hindered 5-hydroxyl group of β-Kdo building block in toluene proceeded smoothly to provide the desired disaccharide in excellent yield with satisfactory β-selectivity. An optimal sequence for the deprotection of the disaccharide skeleton was found to access the disaccharide antigen of Kingella kingae KK01 for further immunological studies.

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Publication details

The article was received on 20 Sep 2018, accepted on 12 Oct 2018 and first published on 12 Oct 2018


Article type: Communication
DOI: 10.1039/C8OB02340A
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    Synthesis of the β-linked GalNAc-Kdo Disaccharide Antigen of the Capsular Polysaccharide of Kingella kingae KK01

    L. Zhuang, Y. Chen, Q. Lou and Y. Yang, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8OB02340A

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