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Sodium carbonate promoted [3 + 2] annulation of α-halohydroxamates and isocyanates

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Abstract

A new [3 + 2] annulation of readily available α-halohydroxamates and isocyanates has been developed. This protocol allows a rapid assembly of various hydantoins in good to high yields as well as a broad substrate scope and good functional group tolerance.

Graphical abstract: Sodium carbonate promoted [3 + 2] annulation of α-halohydroxamates and isocyanates

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Publication details

The article was received on 19 Sep 2018, accepted on 11 Oct 2018 and first published on 11 Oct 2018


Article type: Communication
DOI: 10.1039/C8OB02321B
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Sodium carbonate promoted [3 + 2] annulation of α-halohydroxamates and isocyanates

    S. Sun, R. Chen, G. Wang and J. Wang, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02321B

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