Jump to main content
Jump to site search


Four novel sesquiterpenoids with their anti-Alzheimer's disease activity from Nardostachys chinensis

Author affiliations

Abstract

Nardochinins A–D (1–4), four novel sesquiterpenoids, along with four known ones were isolated from the underground parts of Nardostachys chinensis Batal in ethanol. Their structures were determined by extensive spectroscopic methods and single-crystal X-ray diffraction. Nardochinin A (1) possessed a norsesquiterpene skeleton with an unusual 3/6/5/5 tetracyclic ring system, which had not appeared in natural products. Nardochinins B (2) and C (3) were the first time found naturally occurring sesquiterpenoids with a 4,5-seco-nardosinane skeleton. Besides, compound 3 represented an unprecedented 4,5-seco-nardosinane type norsesquiterpenoid with losing an isopropenyl at C-6 compared with 2 in the structural framework. Nardochinin D (4) was a novel, highly oxygenated valerenane-type sesquiterpenoid possessing a rare 3,12-epoxy group and an unusual 9,11-epoxy group. The anti-Alzheimer's disease (AD) activities of 1–4 were also evaluated using the Caenorhabditis elegans AD pathological model, and nardochinin B (2) had the highest anti-AD activity.

Graphical abstract: Four novel sesquiterpenoids with their anti-Alzheimer's disease activity from Nardostachys chinensis

Back to tab navigation

Supplementary files

Publication details

The article was received on 19 Sep 2018, accepted on 07 Nov 2018 and first published on 07 Nov 2018


Article type: Paper
DOI: 10.1039/C8OB02319K
Citation: Org. Biomol. Chem., 2018, Advance Article
  •   Request permissions

    Four novel sesquiterpenoids with their anti-Alzheimer's disease activity from Nardostachys chinensis

    P. Wu, Y. Yu, Y. Zhao, C. Yu, D. Zhi, F. Qi, D. Fei and Z. Zhang, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02319K

Search articles by author

Spotlight

Advertisements