Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 41, 2018
Previous Article Next Article

C-Alkylation of N-alkylamides with styrenes in air and scale-up using a microwave flow reactor

Author affiliations

Abstract

C-Alkylation of N-alkylamides with styrenes is reported, proceeding in ambient air/moisture to give arylbutanamides and pharmaceutically-relevant scaffolds in excellent mass balance. Various amide and styrene derivatives were tolerated, rapidly affording molecular complexity in a single step; thus highlighting the future utility of this transformation in the synthetic chemistry toolbox. Reaction scalability (up to 65 g h−1 product) was demonstrated using a Microwave Flow reactor, as the first example of a C-alkylation reaction using styrenes in continuous flow.

Graphical abstract: C-Alkylation of N-alkylamides with styrenes in air and scale-up using a microwave flow reactor

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Sep 2018, accepted on 28 Sep 2018 and first published on 29 Sep 2018


Article type: Communication
DOI: 10.1039/C8OB02282H
Citation: Org. Biomol. Chem., 2018,16, 7568-7573

  •   Request permissions

    C-Alkylation of N-alkylamides with styrenes in air and scale-up using a microwave flow reactor

    J. P. Barham, S. Tamaoki, H. Egami, N. Ohneda, T. Okamoto, H. Odajima and Y. Hamashima, Org. Biomol. Chem., 2018, 16, 7568
    DOI: 10.1039/C8OB02282H

Search articles by author

Spotlight

Advertisements