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Issue 43, 2018
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Visible light catalyzed synthesis of quinolines from (aza)-Morita–Baylis–Hillman adducts

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Abstract

A mild and efficient protocol for the synthesis of quinoline scaffolds from (aza)-MBH adducts under visible light catalysis has been established. The reaction involves visible light catalyzed generation of amidyl radicals from (aza)-MBH adducts followed by intramolecular radical cyclization. The reaction exhibits a wide substrate scope, good functional group tolerance and high regioselectivity. This is the first example of utilizing (aza)-MBH adducts for the generation of amidyl radicals and synthesizing aza-heterocycles under visible light photoredox catalyzed reaction conditions.

Graphical abstract: Visible light catalyzed synthesis of quinolines from (aza)-Morita–Baylis–Hillman adducts

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Publication details

The article was received on 12 Sep 2018, accepted on 12 Oct 2018 and first published on 18 Oct 2018


Article type: Paper
DOI: 10.1039/C8OB02260G
Citation: Org. Biomol. Chem., 2018,16, 8155-8159
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    Visible light catalyzed synthesis of quinolines from (aza)-Morita–Baylis–Hillman adducts

    A. K. Chaturvedi and N. Rastogi, Org. Biomol. Chem., 2018, 16, 8155
    DOI: 10.1039/C8OB02260G

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