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Issue 39, 2018
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Activation of the hypervalent fluoroiodane reagent by hydrogen bonding to hexafluoroisopropanol

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Abstract

Hexafluoroisopropan-2-ol (HFIP) is an excellent solvent for promoting fluorinations with the hypervalent fluoroiodane reagent 1 and crucially, it removes the need for transition metals or TREAT-HF activators. The fluoroiodane reagent 1 was used in HFIP to monofluorinate 1,3-ketoesters and to fluorocyclise unsaturated carboxylic acids in excellent yields under mild reaction conditions.

Graphical abstract: Activation of the hypervalent fluoroiodane reagent by hydrogen bonding to hexafluoroisopropanol

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Publication details

The article was received on 07 Aug 2018, accepted on 18 Sep 2018 and first published on 18 Sep 2018


Article type: Paper
DOI: 10.1039/C8OB02236D
Citation: Org. Biomol. Chem., 2018,16, 7170-7173
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    Activation of the hypervalent fluoroiodane reagent by hydrogen bonding to hexafluoroisopropanol

    H. K. Minhas, W. Riley, A. M. Stuart and M. Urbonaite, Org. Biomol. Chem., 2018, 16, 7170
    DOI: 10.1039/C8OB02236D

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