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Issue 43, 2018
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Visible-light-promoted radical acylation/cyclization of alkynoates with aldehydes for the synthesis of 3-acylcoumarins

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Abstract

A new, efficient, and atom-economic visible-light-promoted radical acylation/cyclization of alkynoates with aldehydes was developed for the synthesis of 3-acylcoumarins. The reaction undergoes a domino radical addition/5-exo cyclization, and ester migration to afford the product in moderate to good yields with wide functional group tolerance. The significant feature of this new method is the excellent tolerance of aliphatic aldehydes, which leads to the efficient synthesis of aliphatic 3-acylcoumarins.

Graphical abstract: Visible-light-promoted radical acylation/cyclization of alkynoates with aldehydes for the synthesis of 3-acylcoumarins

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Publication details

The article was received on 10 Sep 2018, accepted on 16 Oct 2018 and first published on 16 Oct 2018


Article type: Paper
DOI: 10.1039/C8OB02232A
Citation: Org. Biomol. Chem., 2018,16, 8196-8204
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    Visible-light-promoted radical acylation/cyclization of alkynoates with aldehydes for the synthesis of 3-acylcoumarins

    Q. Wang, C. Yang and C. Jiang, Org. Biomol. Chem., 2018, 16, 8196
    DOI: 10.1039/C8OB02232A

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