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Issue 43, 2018
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Synthesis of N-arylsulfonamides through a Pd-catalyzed reduction coupling reaction of nitroarenes with sodium arylsulfinates

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Abstract

A novel one-step direct reductive coupling reaction between nitroarenes and sodium arylsulfinates was realized in the presence of an inexpensive Pd/C catalyst. In this procedure, readily available nitroarenes are employed as the nitrogen sources, and sodium arylsulfinates serve as both coupling partners and reductants. The method features high efficiency by using cheap Pd/C with low catalyst loading and good functional group tolerance in the absence of any additional reductants or ligands. This facile and mild synthetic method enables the high efficiency synthesis of functionalized N-arylsulfonamides from readily available substrates.

Graphical abstract: Synthesis of N-arylsulfonamides through a Pd-catalyzed reduction coupling reaction of nitroarenes with sodium arylsulfinates

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Publication details

The article was received on 09 Sep 2018, accepted on 11 Oct 2018 and first published on 15 Oct 2018


Article type: Paper
DOI: 10.1039/C8OB02226G
Citation: Org. Biomol. Chem., 2018,16, 8150-8154
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    Synthesis of N-arylsulfonamides through a Pd-catalyzed reduction coupling reaction of nitroarenes with sodium arylsulfinates

    B. Yang, C. Lian, G. Yue, D. Liu, L. Wei, Y. Ding, X. Zheng, K. Lu, D. Qiu and X. Zhao, Org. Biomol. Chem., 2018, 16, 8150
    DOI: 10.1039/C8OB02226G

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