Issue 43, 2018

Synthesis of N-arylsulfonamides through a Pd-catalyzed reduction coupling reaction of nitroarenes with sodium arylsulfinates

Abstract

A novel one-step direct reductive coupling reaction between nitroarenes and sodium arylsulfinates was realized in the presence of an inexpensive Pd/C catalyst. In this procedure, readily available nitroarenes are employed as the nitrogen sources, and sodium arylsulfinates serve as both coupling partners and reductants. The method features high efficiency by using cheap Pd/C with low catalyst loading and good functional group tolerance in the absence of any additional reductants or ligands. This facile and mild synthetic method enables the high efficiency synthesis of functionalized N-arylsulfonamides from readily available substrates.

Graphical abstract: Synthesis of N-arylsulfonamides through a Pd-catalyzed reduction coupling reaction of nitroarenes with sodium arylsulfinates

Supplementary files

Article information

Article type
Paper
Submitted
09 Sep 2018
Accepted
11 Oct 2018
First published
15 Oct 2018

Org. Biomol. Chem., 2018,16, 8150-8154

Synthesis of N-arylsulfonamides through a Pd-catalyzed reduction coupling reaction of nitroarenes with sodium arylsulfinates

B. Yang, C. Lian, G. Yue, D. Liu, L. Wei, Y. Ding, X. Zheng, K. Lu, D. Qiu and X. Zhao, Org. Biomol. Chem., 2018, 16, 8150 DOI: 10.1039/C8OB02226G

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