Jump to main content
Jump to site search


Rh(III)-Catalyzed dual C–H functionalization of 3-(1H-indol-3-yl)-3-oxopropanenitriles with sulfoxonium ylides or diazo compounds toward polysubstituted carbazoles

Author affiliations

Abstract

A rhodium-catalyzed annulation of 3-(1H-indol-3-yl)-3-oxopropanenitriles with sulfoxonium ylides or diazo compounds has been developed, leading to a series of polysubstituted carbazoles in moderate to good yields. This procedure proceeded with formal Rh(III)-catalyzed (4 + 2) cycloaddition, with the functionalization of 2-C–H bonds of indole in a step-economical procedure. Additionally, this reaction could also be conducted under acidic conditions when diazo compounds were employed as the reaction partners, which was a complement to the annulation of sulfoxonium ylides under weak basic conditions.

Graphical abstract: Rh(iii)-Catalyzed dual C–H functionalization of 3-(1H-indol-3-yl)-3-oxopropanenitriles with sulfoxonium ylides or diazo compounds toward polysubstituted carbazoles

Back to tab navigation

Supplementary files

Publication details

The article was received on 31 Aug 2018, accepted on 01 Nov 2018 and first published on 05 Nov 2018


Article type: Communication
DOI: 10.1039/C8OB02145G
Citation: Org. Biomol. Chem., 2018, Advance Article
  •   Request permissions

    Rh(III)-Catalyzed dual C–H functionalization of 3-(1H-indol-3-yl)-3-oxopropanenitriles with sulfoxonium ylides or diazo compounds toward polysubstituted carbazoles

    Y. Xiao, H. Xiong, S. Sun, J. Yu and J. Cheng, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02145G

Search articles by author

Spotlight

Advertisements