Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 41, 2018
Previous Article Next Article

Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridine and acetamidine hydrochloride

Author affiliations

Abstract

Under catalyst-free conditions, an efficient method for the synthesis of 2-aminopyridine derivatives through the nucleophilic substitution and hydrolysis of 2-fluoropyridine and acetamidine hydrochloride has been developed. This amination uses inexpensive acetamidine hydrochloride as the ammonia source and has the advantages of a high yield, high chemoselectivity and wide substrate adaptability. The results suggest that other N-heterocycles containing fluorine substituents can also complete the reaction via these reaction conditions and yield the target products.

Graphical abstract: Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridine and acetamidine hydrochloride

Back to tab navigation

Supplementary files

Publication details

The article was received on 30 Aug 2018, accepted on 28 Sep 2018 and first published on 28 Sep 2018


Article type: Communication
DOI: 10.1039/C8OB02129E
Citation: Org. Biomol. Chem., 2018,16, 7564-7567

  •   Request permissions

    Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridine and acetamidine hydrochloride

    Y. Li, S. Huang, C. Liao, Y. Shao and L. Chen, Org. Biomol. Chem., 2018, 16, 7564
    DOI: 10.1039/C8OB02129E

Search articles by author

Spotlight

Advertisements