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Issue 2, 2019
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Investigation of tetrazine reactivity towards C-nucleophiles: pyrazolone-based modification of biomolecules

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Abstract

Chemoselective, biocompatible ligation reactions are the key components for efficient and modular access to biomolecular scaffolds. Tetrazine ligation leads to the formation of a mixture of isomers, which makes reaction monitoring, purification and characterization of conjugates difficult. We report herein a modified tetrazine ligation strategy based on the use of a pyrazolone coupling partner, which provides a single molecule conjugate.

Graphical abstract: Investigation of tetrazine reactivity towards C-nucleophiles: pyrazolone-based modification of biomolecules

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Publication details

The article was received on 28 Aug 2018, accepted on 06 Dec 2018 and first published on 06 Dec 2018


Article type: Paper
DOI: 10.1039/C8OB02108B
Citation: Org. Biomol. Chem., 2019,17, 388-396

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    Investigation of tetrazine reactivity towards C-nucleophiles: pyrazolone-based modification of biomolecules

    K. Renault, C. Guillou, P. Renard and C. Sabot, Org. Biomol. Chem., 2019, 17, 388
    DOI: 10.1039/C8OB02108B

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