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New Friedel–Crafts strategy for preparing 3-acylindoles

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Abstract

A selective Friedel–Crafts acylation of indoles via an unusual cleavage of the amide C–N bond was achieved by triflic anhydride activation. This method offers rapid efficient access to high-biological-value 3-acylindoles, performs a series of scrupulous mechanistic studies and offers a strong courage that amide synthons can form new C–C bonds under transition-metal-free conditions.

Graphical abstract: New Friedel–Crafts strategy for preparing 3-acylindoles

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Publication details

The article was received on 27 Aug 2018, accepted on 02 Oct 2018 and first published on 03 Oct 2018


Article type: Communication
DOI: 10.1039/C8OB02094A
Citation: Org. Biomol. Chem., 2018, Advance Article
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    New Friedel–Crafts strategy for preparing 3-acylindoles

    L. Li, Z. Niu and Y. Liang, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02094A

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